By Prof. Dr. Wolfgang Dahr, John Moulds, Phyllis Unger, Dominique Blanchard (auth.), Prof. Dr. med. B. Brinkmann, Dr. med. Klavs Henningsen (eds.)
Read or Download 11th Congress of the Society for Forensic Haemogenetics (Gesellschaft für forensische Blutgruppenkunde e.V.): Copenhagen, August 6–10, 1985 PDF
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Additional info for 11th Congress of the Society for Forensic Haemogenetics (Gesellschaft für forensische Blutgruppenkunde e.V.): Copenhagen, August 6–10, 1985
Isolation and culture of villus stromal cells by the present techniques has improved the growth rate of cells expressing the fetal HLA-haplotypes. The final culture of amniotic fluid cells and villus stromal cells in the microchambers used directly for HLA-determination reduced 27 the background of dead cells observed immediately after trypsinization. The culture of villus stromal cells provides a prenatal HLA-determination about 4 weeks earlier than it is possible to obtain by amniocentesis. It is now possible to obtain the proper material for HLAdetermination, whether it is performed on amniotic fluid or villus cells and whether the purpose is based on Forensic or Medical Genetics.
Split genes. Scient. Am. : Protein in normal cerebrospinal fluid not found in serum. Proc. Soc. Exp. BioI. Med. -H. : Synthesis in E. coli of u1-antitrypsin variants of therapeutic potential for emphysema and thrombosis. , Maniatis, T. : The Structure and Evaluation of the Human ~ -Globin Gene Family. , Marrack, P. : Genetic markers of the antigen-specific T cell receptor locus. J. Exp. Med. : Ficin and papain inhibitor from chicken egg white. Arch. Biochem. Biophys. , Gudmundsson, G. : Abnormal metablism of Y -trace alkaline microprotein.
Advances in Forensic Haemogenetics 1 Edited by B. Brinkmann and K. Henningsen © Springer-Verlag Berlin Heidelberg 1986 S gene Z gene Pittsburgh gene Abnormality Substitution Deficiency Severe deficiency Antitrombin 264 Glu - Val 342 Glu - Lys 358 Met - Arg The Pittsburgh mutation strikes exactly at the crucial Met site at position 358 and gives a complete change of the function of the molecule rendering highly active antitrombin. The amount of antitrypsin in ZZ people is about 15 per cent of the normal level.
11th Congress of the Society for Forensic Haemogenetics (Gesellschaft für forensische Blutgruppenkunde e.V.): Copenhagen, August 6–10, 1985 by Prof. Dr. Wolfgang Dahr, John Moulds, Phyllis Unger, Dominique Blanchard (auth.), Prof. Dr. med. B. Brinkmann, Dr. med. Klavs Henningsen (eds.)