David H. Small BSc, PhD (auth.), Colin J. Barrow BSc's Abeta Peptide and Alzheimer’s Disease: Celebrating a Century PDF

By David H. Small BSc, PhD (auth.), Colin J. Barrow BSc (Hons),PhD, MBA, David H. Small BSc, PhD (eds.)

ISBN-10: 1846284406

ISBN-13: 9781846284403

ISBN-10: 1852339616

ISBN-13: 9781852339616

Abeta Peptide and Alzheimer’s ailment summarizes present wisdom of beta-amyloid peptide (Aß) and its position because the significant wrongdoer in Alzheimer’s affliction (AD), proven via fresh advances in genetics and mind biochemistry.

Written via leaders within the commercial and educational global focusing on this swiftly relocating region, the e-book covers primary biochemical reviews at the Aß peptide, the genetic impression on Aß expression and processing, and diverse advert healing options that concentrate on Aß. even supposing in particular targeting Aß and advert, there's additionally a few dialogue at the similarity and modifications of this peptide and advert with different amyloidogenic illnesses, similar to prion ailment, Parkinson’s and Huntington’s.

This booklet will essentially be of curiosity to advert researchers and clinicians but in addition to researchers of different amyloid diseases.

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Extra resources for Abeta Peptide and Alzheimer’s Disease: Celebrating a Century of Research

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278. , Activation of microglial cells by beta-amyloid pro- 29 tein and interferon-gamma. Nature, 1995. 374 (6523):647-650. 279. , Scavenger receptor-mediated adhesion of microglia to beta-amyloid fibrils. Nature, 1996. 382(6593): 716-719. 280. , Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer’s disease. Proc Natl Acad Sci U S A, 1989. 86(19):76117615. 281. , Complement activation and beta-amyloid-mediated neurotoxicity in Alzheimer’s disease. Res Immunol, 1992.

302. , Dramatic aggregation of Alzheimer Aß by Cu(II) is induced by conditions representing physiological acidosis. J Biol Chem, 1998. 273(21):1281712826. 303. , Copper catalyzed oxidation of Alzheimer Aß. Cell Mol Biol, 2000. 46(4):777-783. 304. , The Aß peptide of Alzheimer’s disease directly produces hydrogen peroxide through metal ion reduction. Biochemistry, 1999. 38(24):7609-7616. 305. , Cu(II) potentiation of Alzheimer Aß neurotoxicity. L. Villemagne et al. duction and metal reduction. J Biol Chem, 1999.

Comparison of neurodegenerative pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein and Alzheimer’s disease. J Neurosci, 1996. 16(18):5795-5811. 203. , Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice. Science, 1996. 274(5284):99-102. 204. , APPSw transgenic mice develop age-related A beta deposits and neuropil abnormalities, but no neuronal loss in CA1. J Neuropathol Exp Neurol, 1997. 56(9):965-973. 205. , Abeta deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein V717F (PDAPP) transgenic mouse.

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Abeta Peptide and Alzheimer’s Disease: Celebrating a Century of Research by David H. Small BSc, PhD (auth.), Colin J. Barrow BSc (Hons),PhD, MBA, David H. Small BSc, PhD (eds.)

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