By Ashutosh Tiwari, Bora Garipcan, Lokman Uzun
The ebook outlines first the significance of additional mobile Matrix (ECM), that's a ordinary floor for many of cells. within the following chapters the impact of organic, chemical, mechanical, and actual houses of surfaces in micro and nano-scale on stem telephone habit are mentioned together with the mechanotransduction. Biomimetic and bioinspired techniques are highlighted for constructing microenvironment of numerous tissues, and floor engineering functions are mentioned in tissue engineering, regenerative medication and diversified form of biomaterials in a variety of chapters of the book.
This booklet brings jointly cutting edge methodologies and techniques followed within the learn and improvement of Advanced Surfaces in Stem cellphone Research. famous around the world researchers planned topics including:
- Extracellular matrix proteins for stem phone fate
- The superficial mechanical and actual homes of matrix microenvironment as stem phone destiny regulator
- Effects of mechanotransduction on stem phone behavior
- Modulation of stem cells habit via bioactive surfaces
- Influence of managed micro and nanoengineered surfaces on stem phone fate
- Nanostructured polymeric surfaces for stem cells
- Laser floor amendment options and stem cells applications
- Plasma polymer deposition: a flexible software for stem telephone research
- Application of bioreactor proposal and modeling thoughts in bone regeneration and augmentation treatments
- Substrates and surfaces for regulate of pluripotent stem phone destiny and function
- Application of biopolymer-based, floor converted units in transplant medication and tissue engineering
- Silk as a ordinary biopolymer for tissue engineering
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Additional info for Advanced Surfaces for Stem Cell Research
30. , Imanishi Y. Regulation of growth and adhesion of cultured cells by insulin conjugated with thermoresponsive polymers. Biotechnol. Bioeng. 53, 339–44, 1997. 31. , et al. Stem cell fate dictated solely by altered nanotube dimension. Proc. Natl. Acad. Sci. U S A 106, 2130–5, 2009. Extracellular Matrix Proteins for Stem Cell Fate 17 32. M. Control of stem cell fate by engineering their micro and nanoenvironment. World J. Stem Cells 7, 37–50, 2015. 33. J. Nanotopographical control of stem cell differentiation.
From blood flow stimuli to external stimulus such as muscle forces and external forces impact on stem cell fate. Mechanical stimuli can effect on many of cellular interactions and play an important role in a variety of disease states such as atherosclerosis, osteoarthritis, and osteoporosis . However, researchers have found it for more than half a century. For example, in a series of experiments in the 1930s and 1940s, Glucksmann demonstrated that cultured chick rudiments under static compression following displacement of the periosteum and perichondrium resulted in cartilaginous tissue formation, whereas tensile stresses promoted bone formation .
Extracellular Matrix Proteins for Stem Cell Fate 19 63. , et al. The promotion of neural progenitor cells proliferation by aligned and randomly oriented collagen nanofibers through beta1 integrin/MAPK signaling pathway. Biomaterials 32, 6737–44, 2011. 64. , et al. Transforming growth factor beta1 and laminin-111 cooperate in the induction of interleukin-16 expression in synovial fibroblasts from patients with rheumatoid arthritis. Ann. Rheum. Dis. 69, 270–5, 2010. 65. Lam BS, Adams GB. Hematopoietic stem cell lodgment in the adult bone marrow stem cell niche.
Advanced Surfaces for Stem Cell Research by Ashutosh Tiwari, Bora Garipcan, Lokman Uzun