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By Peter McLaughlin, Lester E. Robertson, Michael J. Keating (auth.), Fernando Cabanillas M.D., M. Alma Rodriguez M.D. (eds.)

ISBN-10: 1461368510

ISBN-13: 9781461368519

ISBN-10: 1461541298

ISBN-13: 9781461541295

Fernando Cabanillas In 1993, Fisher et al. released the result of a randomized trial evaluating 3 third-generation regimens opposed to the vintage CHOP blend. For a number of years, the oncology neighborhood were confident that the 3rd­ new release regimens have been sincerely better to cut. It got here as a surprise to many who there has been no distinction in final result among the 4 hands of this medical trial. The logical end is that CHOP is pretty much as good as any of the opposite regimens verified in that examine. regrettably, this glorious examine has been misinterpreted by means of many as proving that there has now not been any development within the box of lymphoma over the last twenty years. in addition, it has resulted in a fatalistic perspective within the reasoning of many clinicians who think that 'nothing works greater than CHOP' and for that reason that it isn't worthy checking out new medicinal drugs or constructing novel regimens. besides the fact that, the method in which we circulate ahead within the oncology box is seldom by way of dramatic breakthroughs. often, what seems before everything look to be a leap forward seems later to be only a modest breakthrough. numerous steps ahead finally upload as much as a tremendous boost, yet this boost is going not noted due to the gradual nature of the method. during this quantity, we now have selected to debate numerous of those steps, which we consider are basically creating a confident effect at the box of lymphomas and which quickly may still make a huge distinction in healing results.

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2-Chlorodeoxyadenosine (2-CdA) for the treatment of various haematological malignancies. Eight Symposium July 9-13, Basel, Switzerland, abstract 160. Mol BioI Hematopoiesis. Kahn J, Kaplan L, Northfelt D, et al. (1991). 2-chlorodeoxyadenosine (2-CdA) for AIDSassociated non-Hodgkin's lymphoma (NHL): a phase I study. Proc Am Soc Clin On col 10:34 (abstract). Beutler E, Piro LD, Saven A, et al. (1991). 2-Chlorodeoxyadenosine (2-CdA): a potent chemotherapeutic and immunosuppressive nucleotide. Leuk Lymphoma 5:1-8.

The malignant lymphocytes were small, irregularly shaped cells, which Weisenberger considered to be of intermediate differentiation. Thus, he suggested that MZL was the follicular counterpart of diffuse IDLL. At about the same time that Berard described IDLL, Lennert published his proposed lymphoma classification [5,6]. In his system, now called the Kiel Classification of non-Hodgkin's lymphomas, he described a category of lymphoma that he termed centrocytic lymphoma. This lymphoma was characterized by a homogeneous popUlation of cells with irregular nuclear contours and scant cytoplasm.

A revised European American Classification of lymphoid neoplasms. Blood 84(5):1341-1392. 11. Rodriguez MA, Pugh W, Majlis A, Cabanillas FC (1993). Mantle cell lymphoma: correlation of clinical behavior and histologic pattern. In Proceedings of the 4th International Conference on Malignant Lymphoma, Lugano, Switzerland, p. 22. 12. Majlis A, Pugh W, Rodriguez MA, Cabanillas F (submitted). Mantle cell lymphoma: correlation of clinical outcome and biological features with three histologic variants.

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Advances in Lymphoma Research by Peter McLaughlin, Lester E. Robertson, Michael J. Keating (auth.), Fernando Cabanillas M.D., M. Alma Rodriguez M.D. (eds.)


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